Expression data from testes of the mouse X-chromosome substitution strains

ABSTRACT: To investigate the evolutionary divergence of transcriptional regulation between the mouse subspecies, we performed transcriptome analysis by microarray on testes from the X-chromosome substitution strain, which carries different subspecies-derived X chromosome on the host subspecies genome. Transcription profiling showed that large-scale aberrations in gene expression were occurred on the introgressed X chromosome. This improper expression was restored by introducing chromosome 1 from the same donor strain as the X chromosome, suggesting that the genetic incompatibility between trans-acting regulatory gene(s) on chromosome 1 and X-linked downstream genes might be a cause of the misregulation. Testes were collected from 5- and 7-day-old males for RNA extraction and the microarray experimen

ORGANISM(S): Mus musculus

SUBMITTER: Ayako Oka 

PROVIDER: E-GEOD-50687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress