Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

ABSTRACT: We performed ChIP-seq of histone modifications and RNA-seq in WT and kmt6 mutant Fusarium graminearum grown in high and low nitrogen conditions. Two replicates of RNA seq for WT and kmt6 strains at high and low nitrogen. Four histone modification ChIPs in WT and kmt6 mutant strains at high and low nitrogen, plus two histone modifications in a kmt6+ complemented strain at high nitrogen.

ORGANISM(S): Fusarium graminearum

SUBMITTER: Kristina Smith

PROVIDER: E-GEOD-50689 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters.

Connolly Lanelle R LR Smith Kristina M KM Freitag Michael M

PLoS genetics 20131031 10

The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a histone modification associated with gene silencing. H3K27me3 was found predominantly in regions that lack syn ...[more]

PMID: 24204317

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Dataset Information

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Publications

The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters.

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