Correlation between STAT3 binding presence and gene expression levels in subtypes of diffuse large B cell lymphoma
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jennifer Hardee
PROVIDER: E-GEOD-50724 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
STAT3 targets suggest mechanisms of aggressive tumorigenesis in diffuse large B-cell lymphoma.
Hardee Jennifer J Ouyang Zhengqing Z Zhang Yuping Y Kundaje Anshul A Lacroute Philippe P Snyder Michael M
G3 (Bethesda, Md.) 20131209 12
The signal transducer and activator of transcription 3 (STAT3) is a transcription factor that, when dysregulated, becomes a powerful oncogene found in many human cancers, including diffuse large B-cell lymphoma. Diffuse large B-cell lymphoma is the most common form of non-Hodgkin's lymphoma and has two major subtypes: germinal center B-cell-like and activated B-cell-like. Compared with the germinal center B-cell-like form, activated B-cell-like lymphomas respond much more poorly to current thera ...[more]
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