Foxp1 is a rate-limiting and essential negative regulator of Tfh cell differentiation

ABSTRACT: CD4+ T follicular helper (Tfh) cells are essential for germinal center (GC) and high-affinity antibody responses. Yet the regulation that determines the initial development of Tfh cells is still largely unknown. Here we find that transcription factor Foxp1, previously shown to be essential in maintaining T cell quiescence, is a rate-limiting and essential negative regulator of Tfh cell differentiation. NaM-CM-/ve CD4+ T cells constitutively express Foxp1A, and stimulation through the T cell receptor (TCR) transiently induces the expression of a shorter Foxp1D isoform. In T cell-dependent (TD) humoral responses, CD4+ T cells deficient in all Foxp1 isoforms preferentially differentiate into Tfh cells, resulting in substantially increased GC and antibody responses. This negative regulation of

ORGANISM(S): Mus musculus

SUBMITTER: Priyankara Wickramasinghe 

PROVIDER: E-GEOD-50725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress