Transcription profiling of C57BL/6NIA mouse hippocampus to survey age-related changes in mRNA levels.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Pavlidis
PROVIDER: E-GEOD-5078 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. Keywords: age comparison
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