Pouch transcriptional differences between UC and FAP indicate altered immune response.

ABSTRACT: A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and selected patients with ulcerative colitis (UC). However, this surgical treatment often associates with a long-term complication, pouchitis, which occurs mostly in UC patients. To better define the molecular background of pouchitis, the microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients operated for UC and FAP, respectively. A number of 4771 genes was significantly differentiating uninflamed from inflamed mucosal samples, and their functional features were represented mostly by alerted metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly e

ORGANISM(S): Homo sapiens

SUBMITTER: Krzysztof Goryca 

PROVIDER: E-GEOD-50788 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress