Transcription profiling of human astrocytes to create a toxicogenomic profile of Mn

ABSTRACT: Exposure of adult humans to manganese (Mn) has long been known to cause neurotoxicity. Recent evidence also suggests that exposure of children to Mn is associated with developmental neurotoxicity. Astrocytes are critical for the proper functioning of the nervous system, and they play active roles in neurogenesis, synaptogenesis and synaptic neurotransmission. In this report, to help elucidate the molecular events underlying Mn neurotoxicity, we systematically identified the molecular targets of Mn in primary human astrocytes by using microarray gene expression profiling and computational data analysis algorithms. We found that Mn altered the expression of diverse genes ranging from those encoding cytokines and transporters to signal transducers and transcriptional regulators. Particul

ORGANISM(S): Homo sapiens

SUBMITTER: Sarah Mense 

PROVIDER: E-GEOD-5079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress