Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood.

ABSTRACT: Lifestyle intervention can improve insulin sensitivity in obese youth yet few studies have examined the biological mechanisms underlying improvements. Therefore, the purpose of this study was to explore biological pathways associated with intervention-induced improvements in insulin sensitivity. Fifteen (7M/8F) overweight/obese (BMI percentile=96.3M-BM-11.1) Latino adolescents (15.0M-BM-10.9 years) completed a 12-week lifestyle intervention that included weekly nutrition education and 180 minutes of moderate-vigorous exercise per week. Insulin sensitivity, estimated by an oral glucose tolerance test and the Matsuda Index, increased 29.2% post intervention (2.4M-BM-10.3 to 3.1M-BM-10.3, p=0.01). Global microarray analysis profiling from whole blood was performed to examine changes in gene e

ORGANISM(S): Homo sapiens

SUBMITTER: Gabriel Shaibi 

PROVIDER: E-GEOD-50800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress