Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kaoru Mogushi
PROVIDER: E-GEOD-50836 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tanaka Ken-Ichiro K Ishihara Tomoaki T Sugizaki Toshifumi T Kobayashi Daisuke D Yamashita Yasunobu Y Tahara Kayoko K Yamakawa Naoki N Iijima Kumiko K Mogushi Kaoru K Tanaka Hiroshi H Sato Keizo K Suzuki Hidekazu H Mizushima Tohru T
Nature communications 20130101
The clinical treatment of chronic obstructive pulmonary disease (COPD) requires not only an improvement of airflow by bronchodilation but also the suppression of emphysema by controlling inflammation. Here we screen a compound library consisting of clinically used drugs for their ability to prevent elastase-induced airspace enlargement in mice. We show that intratracheal administration or inhalation of mepenzolate bromide, a muscarinic antagonist used to treat gastrointestinal disorders, decreas ...[more]