Yuan- microRNAs upregulated in Ep300-overexpressing mouse heart

ABSTRACT: Objective: To characterize downstream effectors of p300 acetyltransferase in the myocardium. Background: Acetyltransferase p300 is a central driver of the hypertrophic response to increased workload, but its biological targets and downstream effectors are incompletely known. Methods and Results: Mice expressing a myocyte-restricted transgene encoding acetyltransferase p300, previously shown to develop spontaneous hypertrophy, were observed to undergo robust compensatory blood vessel growth together with increased angiogenic gene expression. Chromatin immunoprecipitation demonstrated binding of p300 to the enhancers of the angiogenic regulators Angpt1 and Egln3. Interestingly, p300 overexpression in vivo was also associated with relative upregulation of several members of the anti-angiog

ORGANISM(S): Mus musculus

SUBMITTER: Nanette Bishopric 

PROVIDER: E-GEOD-50843 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress