Genome-wide maps of chromatin state in Germinal Center B cells.

ABSTRACT: Protection against deadly pathogens requires the production of high-affinity antibodies by B cells. High-affinity antibody-forming cells are generated in germinal centers (GC) as a result of a developmental program that is commonly altered in B cell malignancies. Identification of regulators of the GC response is crucial to develop targeted therapies for GC B cell dysfunctions including lymphomas. The Histone H3 lysine-27 methyltransferase Enhancer of Zeste homolog 2 (EZH2) is highly expressed in GC B cells and often constitutively activated in GC-derived Non-Hodgkin lymphomas (NHL), but its function in these cells remains largely unknown. Herein, we show that Ezh2 inactivation in mouse GC B cells causes a profound impairment in GC responses, memory B cell formation and humoral immunity. M

ORGANISM(S): Mus musculus

SUBMITTER: Stefano Casola 

PROVIDER: E-GEOD-50912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress