Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Comparison of metastasis-inclined microenvironment (MIM) and metastasis-averse microenvironment (MAM) HCC patients

ABSTRACT: To determine the role of the hepatic microenvironment in HCC metastasis, we compared the gene expression profiles of 20 noncancerous surrounding hepatic tissues from two HCC patient groups, those with primary HCC together with venous metastasis which we termed a metastasis-inclined microenvironment (MIM) and those with HCC without detectable metastasis, which we termed a metastasis-averse microenvironment (MAM). There were a total of 20 cDNA microarrays performed, comparing 9 MIM or 11 MAM HCC patient samples to a common reference pool of 8 normal liver tissues.

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Wang

PROVIDER: E-GEOD-5093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.

Budhu Anuradha A Forgues Marshonna M Ye Qing-Hai QH Jia Hu-Liang HL He Ping P Zanetti Krista A KA Kammula Udai S US Chen Yidong Y Qin Lun-Xiu LX Tang Zhao-You ZY Wang Xin Wei XW

Cancer cell 20060801 2

Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by the liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is associated with noncancerous hepatic tissues from metastatic HCC patients. This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine shift in the venous metastasis-associated liver microenvironment ...[more]

PMID: 16904609

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Dataset Information

Comparison of metastasis-inclined microenvironment (MIM) and metastasis-averse microenvironment (MAM) HCC patients

Publications

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.

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