Expression data from Saccharomyces cerevisiae strains carrying the rna14-1 or the rna15-1 allele

ABSTRACT: In the yeast Saccharomyces cerevisiae, cleavage factor I (CFI) and cleavage and polyadenylation factor (CPF) build the core of the transcription termination machinery. CFI comprises the Rna14, Rna15, Pcf11, and Clp1 proteins, as well as the associated Hrp5 RNA-binding protein. We found that CFI participates in the DNA damage response and that rna14-1 shows synthetic growth defects with mutants of different repair pathways, including homologous recombination, non-homologous end joining, post replicative repair, mismatch repair, and nucleotide excision repair, implicating that impaired RNAPII termination and 3’-end processing decreases the cellular tolerance for DNA damage. Beyond replication progression defects, we found that bypass of the G1/S checkpoint in rna14-1 cells leads to synthet

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Andrés Aguilera 

PROVIDER: E-GEOD-50947 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress