MDSC exacerbate acute hepatitis, mature and loose suppressor function CD40 dependent

ABSTRACT: Myeloid-derived suppressor cells (MDSC) represent a heterogeneous population of immature myeloid cells that accumulate in blood, liver, spleen and tumors upon chronic inflammation and tumor development in patients and mice. Acute hepatitis is characterized by a fast infiltration of inflammatory cells in the liver and increased enzymatic activity at this organ that could lead into liver fibrosis and cirrhosis. We have studied the biology of hepatic MDSC in acute hepatitis. Unexpectedly, hepatic MDSC, which accumulate in the liver of mice bearing subcutaneous tumors, failed to suppress inflammatory responses upon Con A injection, but instead were responsible for exacerbating acute liver damage. Phenotypic, genetic and functional studies demonstrated rapid changes of hepatic MDSC from a suppr

ORGANISM(S): Mus musculus

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-50949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress