Transcription profiling of Drosophila melanogaster Canton S DHR96 mutants treated with the xenobiotic phenobarbital, DHR96 is an ortholog of xenobiotic nuclear receptors PXR and CAR, and plays a role in mediating xenobiotic responses in Drosophila

ABSTRACT: Phenobarbital is a well studied xenobiotic compound. In this study, we describe the genomic responses in fruit flies and examine whether animals mutant for DHR96, an ortholog of xenobiotic nuclear receptors PXR and CAR, plays a role in mediating xenobiotic responses in Drosophila. Experiment Overall Design: Canton S is a commonly used wild type control strain for xenobiotic studies. Wild type or DHR96 mutant flies were starved overnight and then exposed to either sucrose alone or sucrose supplemented with 0.3% Phenobarbital.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Kirst King-Jones 

PROVIDER: E-GEOD-5096 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress