DKK1 expression is down-regulated in the lymph node pre-metastatic niche in esophageal cancer

ABSTRACT: Lymph node metastasis is a poor prognosis indicator in esophageal cancer. Although tumor spreading currently forms the main basis for therapy selection, the molecular mechanisms underlying the metastatic pathway remain insufficiently understood. Several studies aimed to investigate these mechanisms but focused mainly on regulatory patterns in the tumors themselves and/or the invaded lymph nodes. To date no study has yet investigated the potential changes on transcription level, which take place within the yet non-invaded niche. Here we provide a comprehensive description of these regulations in patients. In this study the transcriptomic profiles of regional lymph nodes were determined for two patient groups: patients classified as pN1 (metastasis) or pN0 (no metastasis) respectively. All

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Streichert 

PROVIDER: E-GEOD-51021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress