DNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq2]

ABSTRACT: DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coincides with an upregulation of critical genes of the myelination process. More importantly, we found that, in addition to expression of DNA methyltransferases and demethylases, the levels of S-adenosylmethionine (SAMe), the principal biological methyl donor, could also play a critical role in regulating DNA methylation during myelination and in the pathogenesis of diabetic neuropathy. In summary, this study provides compelling evidence that SAMe levels need to be tightly controlled to prevent aberr

ORGANISM(S): Mus musculus

SUBMITTER: Jose Lavin 

PROVIDER: E-GEOD-51031 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress