Transcription profiling of rat kidney iosgrafts from live or brain dead donors with samples taken before and after transplantation

ABSTRACT: The clinical results obtained with organ allografts from marginal or extended donors are less satisfactory over both the short-term and long-term than the outcome of grafting from living donors. Early postoperative graft function depends on several pretransplant factors, with the major donor influences being brain death (BD) and ischemia/reperfusion(I/R) injury. The effects of BD and I/R injury not only reduce the number of functioning nephrons, but also trigger a host immune response to the grafted kidney. It has been hypothesized that allografts from marginal sources may not be biologically inert at the time of surgery, but may already be programmed to initiate or amplify a host response. To exclude the effects of allogenicity, we established a rat renal isograft model using dead donors

ORGANISM(S): Rattus norvegicus

SUBMITTER: Mamoru Kusaka 

PROVIDER: E-GEOD-5104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress