Cholesterol regulates DAF-16 nuclear localization and fasting-induced longevity in C. elegans

ABSTRACT: Cholesterol has attracted significant attention as a possible lifespan regulator. It has been reported that serum cholesterol levels have an impact on mortality due to age-related disorders such as cardiovascular disease. Diet is also known to be an important lifespan regulator. Dietary restriction retards the onset of age-related diseases and extends lifespan in various organisms. Although cholesterol and dietary restriction are known to be lifespan regulators, it remains to be established whether cholesterol is involved in dietary restriction-induced longevity. Here, we show that cholesterol deprivation suppresses longevity induced by intermittent fasting, which is one of the dietary restriction regimens that effectively extend lifespan. We also found that cholesterol is required for the

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Eisuke Nishida 

PROVIDER: E-GEOD-51046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress