A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma

ABSTRACT: Identification of differential gene regulation pattern in human liposarcoma The FUS-CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. In order to dissect its functional role in this context, we stably overexpressed this protein in SW872 liposarcoma and HT1080 fibrosarcoma cell lines, and were able to demonstrate that forced expression of FUS-CHOP significantly increases migration and invasion, as well as enhance lung and liver metastasis in the in vivo chicken chorioallantoic membrane (CAM) model, that is proliferation independent. Additionally, FUS-CHOP enhances the expression of matrix-metalloproteinases -2 and -9, and trans

ORGANISM(S): Homo sapiens

SUBMITTER: Nitin Patil 

PROVIDER: E-GEOD-51049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress