Transcription profiling of human skeletal muscle from Hiv-Infected Men experiencing weight loss treated with testosterone

ABSTRACT: Context: Although androgen treatment increases muscle mass in HIV-infected men, the underlying mechanisms are poorly understood. Analysis of genome-wide microarray data obtained from skeletal muscle biopsies can be used to profile androgen-regulated pathways. Objective: To identify genes and pathways associated with testosterone treatment and myogenesis in the context of HIV-infected men using genome-wide microarray analysis of skeletal muscle biopsies. Results: A significant weight gain was observed in subjects treated with testosterone compared to placebo (+2.05 kgs and â??1.07 kgs, respectively; P = 0.003) as well as gains in DEXA lean; mass (2.93 kgs vs. 0.35 kgs, respectively; P = 0.003). Microarray expression profiles and RTPCR validation of RNA after 14 days of treatment indicated t

ORGANISM(S): Homo sapiens

SUBMITTER: Monty Montano 

PROVIDER: E-GEOD-5106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress