Dataset Information
Transcription profiling of human primary and secondary glioblastomas
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cho-Lea Tso
PROVIDER: E-GEOD-5107 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Primary glioblastomas express mesenchymal stem-like properties.
Molecular cancer research : MCR 20060901 9
Glioblastoma is the most common and aggressive primary brain cancer. Recent isolation and characterization of brain tumor-initiating cells supports the concept that transformed neural stem cells may seed glioblastoma. We previously identified a wide array of mesenchymal tissue transcripts overexpressed in a broad set of primary glioblastoma (de novo) tumors but not in secondary glioblastoma (derived from lower-grade) tumors, low-grade astrocytomas, or normal brain tissues. Here, we extend this o ...[more]
