Opposing Effects of HIF1M-NM-1 and HIF2M-NM-1 on Chromaffin Cell Phenotypic Features and Tumor Cell Proliferation: Insights from MAX [human]

ABSTRACT: Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To establish whether PPGL phenotypic differences reflect a MAX-mediated mechanism and opposing influences of HIF2M-NM-1 and HIF1M-NM-1, we combined observational investigations in PPGLs and gene-manipulation studies in two pheochromocytoma cell lines. In cell lines lacking Max, re-expression of the gene resulted in maturation of phenotypic features and decreased cell cycle progression. In cell lines lacking Hif2M-NM-1, overexpression of the gene led to immature phenotypic features, failure of dexamethasone to induce differentiation and increased proliferation. HIF1M-NM-1 has opposing actions to HIF2

ORGANISM(S): Homo sapiens

SUBMITTER: Mercedes Robledo 

PROVIDER: E-GEOD-51081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress