Analysis of cord blood CD4T cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Lo-Man
PROVIDER: E-GEOD-51133 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.
Zhang Xiaoming X Mozeleski Brian B Lemoine Sebastien S Dériaud Edith E Lim Annick A Zhivaki Dania D Azria Elie E Le Ray Camille C Roguet Gwenaelle G Launay Odile O Vanet Anne A Leclerc Claude C Lo-Man Richard R
Science translational medicine 20140501 238
The T cell compartment is considered to be naïve and dedicated to the development of tolerance during fetal development. We have identified and characterized a population of fetally developed CD4 T cells with an effector memory phenotype (TEM), which are present in cord blood. This population is polyclonal and has phenotypic features similar to those of conventional adult memory T cells, such as CD45RO expression. These cells express low levels of CD25 but are distinct from regulatory T cells be ...[more]
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