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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Glomerulonephritis in BXSB/MpJ-Yaa mice

ABSTRACT: Analysis of glomeruli isolated from kidneys of 4 month male BXSB/MpJ-Yaa. The BXSB/MpJ-Yaa mouse strain is a lupus-prone model. Results provide insight into the pathogenic mechanisms linked to glomerulonephritis in BXSB/MpJ-Yaa mice. The glomeruli were isolated from 6 BXSB/MpJ-Yaa (glomerulonephritis model) and BXSB/MpJ-Yaa+ (control). 6 glomerular populations of each strain were devided into 3 groups (1 group / 2 populations). 3 glomerulonephritis models versus 3 controls analysis was performed. BXSB/MpJ-Yaa is a recombinant inbred strain developed originally from a C57BL/6 female mouse and a SB/Le male mouse. Yaa (Y-linked autoimmune accelerator locus) localizing on the Y chromosome of BXSB/MpJ-Yaa male mice is the result of a duplication of an about 4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. BXSB/MpJ-Yaa+ (control) male mice carry the wild-type Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ-Yaa male mice.

ORGANISM(S): Mus musculus

SUBMITTER: Junpei Kimura

PROVIDER: E-GEOD-51230 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Glomerulonephritis in BXSB/MpJ-Yaa mice

Project description:Analysis of glomeruli isolated from kidneys of 4 month male BXSB/MpJ-Yaa. The BXSB/MpJ-Yaa mouse strain is a lupus-prone model. Results provide insight into the pathogenic mechanisms linked to glomerulonephritis in BXSB/MpJ-Yaa mice.

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Expression data from TNF-stimulated mouse glomeruli

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Mus musculus

Project description:Glomerulonephritis in BXSB/MpJ-Yaa mice

| PRJNA221777 | ENA

microRNA sequencing in kidney glomeruli from diabetic and control mice

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MicroRNA expression in the glomerulus of C57BL/6 mice and B6.MRLc1 glomerulonephritis mice

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2020-05-15 | PXD018326 | Pride

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