Temporal Transcriptomic Signatures Associated with Post-viral Bronchiolitis Sequelae in Rats

ABSTRACT: Early life respiratory viral infections and atopic characteristics are significant risk factors for the development of childhood asthma. It is hypothesized that repeated respiratory viral infections might induce structural remodeling by interfering with the normal process of lung maturation; however, the specific molecular processes that mediate these developments are not understood. To define relevant molecular pathways, we used a well-established Sendai virus infection model in weanling rats to compare transcriptome signatures between a post-infection asthma prone susceptible strain (BN) and a post-infection asthma resistant strain (F344). Specific to this weanling model and not described in adult models, Sendai virus infection in the susceptible strain resulted in morphological abnormal

ORGANISM(S): Rattus norvegicus

SUBMITTER: Xin Sun 

PROVIDER: E-GEOD-51267 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress