Transcription profiling of mouse lung treated with carcinogens and controls to evaluate carcinogenicity and identify biomarkers

ABSTRACT: Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures (two years) in mice and rats and costing $2 to $4 million per chemical. Since there are approximately 80,000 chemicals registered for commercial use in the United States and 2,000 more are added each year, applying animal bioassays to all chemicals of concern is clearly impossible. To efficiently and economically identify carcinogens prior to widespread use and human exposure, alternatives to the two-year rodent bioassay must be developed. In this study, animals were exposed for 13 weeks to two

ORGANISM(S): Mus musculus

SUBMITTER: Russell Scott Thomas 

PROVIDER: E-GEOD-5127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress