Transcription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1

ABSTRACT: Ocular pigment epithelium (PE) cells promote the generation of T regulators (PE-induced Treg cells). Moreover, T cells exposed to PE acquire the capacity to suppress the activation of bystander T cells via TGFbeta. Membrane-bound TGFbeta on iris PE cells interacts with TGFbeta receptors on T cells, leading to the conversion of T cells to CD8(+) Treg cells via a cell contact-dependent mechanism. Conversely, soluble forms of TGFbeta produced by retinal PE cells can convert CD4(+) T cells into Treg cells in a manner that is independent of cell contact. In this study, we looked at the expression of immunoregulatory factors (TGFbeta, thrombospondins, CD59, IL-1 receptor antagonist, etc.) in PE cells as identified via an oligonucleotide microarray. Several thrombospondin-binding molecules were d

ORGANISM(S): Mus musculus

SUBMITTER: Yuri Futagami 

PROVIDER: E-GEOD-5134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress