Conservation of mouse-human trans-regulatory circuitry despite high cis-regulatory divergence

ABSTRACT: The basic body plan and major physiological axes have been highly conserved during mammalian evolution, yet only a small fraction of the human genome sequence appears to be subject to evolutionary constraint. To quantify cis- versus trans-acting contributions to mammalian regulatory evolution, we performed genomic DNase I footprinting of the mouse genome across 25 cell and tissue types, collectively defining ~8.6 million transcription factor (TF) occupancy sites at nucleotide resolution. Here we show that mouse TF footprints conjointly encode a regulatory lexicon that is ~95% similar with that derived from human TF footprints. However, only ~20% of mouse TF footprints have human orthologues. Despite substantial turnover of the cis-regulatory landscape, nearly half of all pairwise regulator

ORGANISM(S): Homo sapiens

SUBMITTER: ENCODE DCC 

PROVIDER: E-GEOD-51341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress