Metabolic programs orchestrated by the activated Ha-ras and Îroteins in mouse liver tumors [protein]

ABSTRACT: The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth of cells harboring oncogene mutations in Ha-ras, B-raf, or Ctnnb1. Here, we have characterized mouse liver tumors harboring either Ctnnb1 or Ha-ras mutations via integrated molecular profiling at the transcriptional and translational and post-translational levels. In addition, metabolites of the intermediary metabolism were quantified by high resultion 1H magic angle nuclear magnetic resonance (HR-MAS NMR). We have identified tumor characteristic genotype-specific differences in mRNA and miRNA expression, protein levels, and post-translational modifications and in metabolite levels that facilitate the molecular and biochemical strat

ORGANISM(S): Mus musculus

SUBMITTER: Johannes Eichner 

PROVIDER: E-GEOD-51357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress