Transcription profiling of mouse embryonic stem cells reveals Hex acts with I-catenin to regulate anterior-posterior axis

ABSTRACT: In Xenopus, establishment of the anterior-posterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGF-β. There are also a number of transcription factors that feedback upon these pathways. The homeodomain protein Hex, an early marker of anterior positional information, acts as a transcriptional repressor suppressing induction and propagation of the Spemman organiser while specifying anterior identity. We show that Hex promotes anterior identity by amplifying the activity of canonical Wnt signalling. Hex exerts this activity by inhibiting the expression of Tle-4, a member of the Groucho family of transcriptional co-repressors that we identified as a Hex target in embryonic stem (ES) cells and Xenopus embryos. This Hex-mediated enhancement of Wnt signalling resu

ORGANISM(S): Mus musculus

SUBMITTER: Joshua Brickman 

PROVIDER: E-GEOD-5141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress