Expression data from oxaliplatin-treated tumors from mice pre-treated or not with antibiotics cocktail

ABSTRACT: The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here we show that disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy. In antibiotic-treated or germ-free mice, tumor-infiltrating myeloid-derived cells responded poorly to therapy, resulting in lower cytokine production and tumor necrosis after CpG-oligonucleotide treatment, and deficient production of reactive oxygen species and cytotoxicity following chemotherapy. Thus, optimal responses to cancer therapy require an intact commensal microbiota that medi

ORGANISM(S): Mus musculus

SUBMITTER: Amiran Dzutsev 

PROVIDER: E-GEOD-51414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress