Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells

ABSTRACT: The myometrium is an important reproductive tissue composed primarily of smooth muscle cells. Contractility of the myometrial smooth muscle cells during the estrous cycle and pregnancy is modulated by estrogen. Despite much research, little is known about the molecular mechanism by which estrogen regulates myometrial contractility. This study investigates global gene expression profile of cultured human uterine smooth muscle cells (hUtSMCs) following 17M-NM-2-estradiol (E2) treatment using cDNA microarray technology. In response to E2 treatment 540 genes were identified as significantly differentially expressed. Gene ontology analysis identified several significant biological processes for these genes including muscle contraction, gland development, cell migration, cell adhesion, apoptosis

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Cairns 

PROVIDER: E-GEOD-51470 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress