Molecular and physiological adaptations of Lactococcus lactis at near-zero growth rates

ABSTRACT: This paper describes the molecular and physiological adaptations of Lactococcus lactis during the transition from a growing to a near-zero growth state using carbon-limited retentostat cultivation. Metabolic and transcriptomic analyses revealed that metabolic patterns shifted between homolactic and mixed-acid fermentation during the retentostat cultivation, which appeared to be controlled at the transcription level of the corresponding pyruvate-dissipation enzyme pathway encoding genes. Furthermore, during extended retentostat cultivation, cells continued to consume several amino acids, but also produced specific amino acids subsets, which may derive from the conversion of glycolytic intermediates. Under conditions of extremely low carbon availability, carbon catabolite repression was prog

ORGANISM(S): Lactococcus lactis

SUBMITTER: Michiel Wels 

PROVIDER: E-GEOD-51494 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress