Peripheral blood mononuclear cell- and cortical bone-derived transcriptional profiles

ABSTRACT: Large-scale transcriptional profiling has enormous potential for discovery of osteoporosis susceptibility genes and for identification of the molecular mechanisms by which these genes and associated pathways regulate bone maintenance and turnover. A potential challenge in the use of this method for the discovery of osteoporosis genes is the difficulty of obtaining bone tissue samples from large numbers of individuals. In this study, we tested the applicability of using peripheral blood mononuclear cell (PBMC)-derived transcriptional profiles as a surrogate to cortical bone transcriptional profiles to address questions of skeletal genetics. We used a well-established and genetically well-characterized nonhuman primate model for human bone maintenance and turnover. We determined that a high

ORGANISM(S): Papio hamadryas

SUBMITTER: Heather Coan 

PROVIDER: E-GEOD-51495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress