Direct Conversion of Human Fibroblasts into Neuronal Restricted Progenitors

ABSTRACT: Neuronal restricted progenitors (NRPs) represent a type of transitional intermediate cells that lie between multipotent neural progenitors (NPs) and terminal differentiated neurons during neurogenesis. These NRPs have the ability to self-renew and differentiate into neurons, but not into glial cells, which is considered as an advantage for cellular therapy of human neurodegenerative diseases. However, difficulty in the extraction of highly purified NPRs from normal nervous tissue prevents further studies and applications. In this study, we reported conversion of human fetal dermal fibroblasts into human induced neuronal restricted progenitors (hiNRPs) in seven days by using just three defined factors: Sox2, c-Myc, and either Brn2 or Brn4. The hiNRPs exhibited distinct neuronal characterist

ORGANISM(S): Homo sapiens

SUBMITTER: Qingjian Zou 

PROVIDER: E-GEOD-51580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress