Innate and adaptive immunity in zebrafish: time course (zebrafish)

ABSTRACT: The interaction between fungal pathogen and host innnate and adaptive immunity during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. Time-course microarray data following primary and secondary infection of zebrafish by Candida albicans were obatined. From this set of data, we constructed two intracellular proteinM-bM-^@M-^Sprotein interaction (PPI) networks for primary and secondary responses of the host. Each fish in the first group was intraperitoneally injected with 1 M-CM-^W 10E5 and 1 M-CM-^W 10E7 CFU C. albicans at day 0 and 14, respec

ORGANISM(S): Danio rerio

SUBMITTER: Yung-Jen Chuang 

PROVIDER: E-GEOD-51603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress