Transcriptional regulation in pluripotent stem cells by Methyl CpG binding protein 2 (MeCP2)

ABSTRACT: Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on the X chromosome, RTT is manifested in a X-linked dominant manner. Investigation using murine MeCP2 null models and post-mortem human brain tissues has contributed to understanding the molecular and physiological function of MeCP2. In addition, RTT models using human induced pluripotent stem cells derived from RTT patients (RTT-iPSCs) provide novel resources to elucidate the regulatory mechanism of MeCP2. Previously, we obtained clones of female RTT-iPSCs that express either wild type or mutant

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshiaki Tanaka 

PROVIDER: E-GEOD-51607 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress