Transcriptome profiling in Engrailed2 knockout mice reveals common molecular pathways associated with ASD.

ABSTRACT: Background: Transcriptome analysis has been used in autism spectrum disorder (ASD) to unravel common pathogenic pathways based on the assumption that distinct rare genetic variants or epigenetic modifications affect common biological pathways dysregulated in ASD. To unravel recurrent ASD-related neuropathological mechanisms, we took advantage of the En2-/- mouse model and performed transcriptome profiling on cerebellar and hippocampal adult tissues. Methods: En2-/- and WT cerebellar and hippocampal tissue from littermate mice were assessed for differential gene expression using microarray hybridization followed by RankProd analysis. To identify functional categories overrepresented in the differentially expressed genes we used the BIOBASE ExPlain system and mouse phenotype ontology databa

ORGANISM(S): Mus musculus

SUBMITTER: Erik Dassi 

PROVIDER: E-GEOD-51612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress