Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

ABSTRACT: Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the first step in such an endeavor for prostate cancer. We provide a comprehensive annotation of the 77 known risk loci, based upon highly correlated variants in biologically relevant chromatin annotations- we identified 727 such potentially functional SNPs. We also provide a detailed account of possible protein disruption, microRNA target sequence disruption and regulatory response element disruption of all correlated SNPs at r^2≥0.5. Greater than 88% of the 727 SNPs fall within putative enhancers, many of which alter critical residues in the response elements of tra

ORGANISM(S): Homo sapiens

SUBMITTER: Peggy Farnham 

PROVIDER: E-GEOD-51621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress