Effect of enforced BMP4 expression on gene expression profile of 4T1.2 whole primary murine mammary tumours

ABSTRACT: BMP4 is down-regulated in metastatic human and murine mammary tumours. Here we determined the effect of ectopic mouse Bmp4 re-expression on global gene expression patterns in orthotopic primary mammary tumours in syngeneic Balb/c mice. Breast cancer is a major cause of cancer related death in women, due to the development of metastatic disease in vital organs. Metastasis can be facilitated by tumor induced MDSC, which requires understanding. We have confirmed that BMP4 is a potent suppressor of breast cancer metastasis, but for potential clinical application, it is important to understand how BMP4 acts to suppress metastasis. Here, we report one mechanism by which BMP4 can inhibit metastasis. Mice bearing highly metastatic mammary tumors present with elevated numbers of myeloid derived sup

ORGANISM(S): Mus musculus

SUBMITTER: Cameron Johnstone 

PROVIDER: E-GEOD-51632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress