Stem Cell Quiescence acts as a tumor suppressor mechanism in hair follicle initiated squamous tumors

ABSTRACT: In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin1-4. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma (SCC) and undergo defined cycles of quiescence and activation. The data presented here show that HFSCs are unable to initiate tumors during the quiescent phase of the hair cycle, indicating that the mechanisms that keep HFSCs dormant are dominant to the gain of oncogenes (Ras) or the loss of tumor suppressors (p53). Furthermore, Pten activity is necessary for quiescence based tumor suppression, as its deletion alleviates tumor suppression without affecting proliferation. These data demonst

ORGANISM(S): Mus musculus

SUBMITTER: William Lowry 

PROVIDER: E-GEOD-51635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress