Involvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.

ABSTRACT: Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a common pattern of transcriptional changes in a small subset of genes named atrophy-related genes or atrogenes. Whether microRNAs play a role in the atrophy program and muscle loss is debated. To understand the involvement of miRNAs in atrophy we performed miRNA expression profiling of mouse muscles under wasting conditions such as fasting, denervation, diabetes and cancer cachexia. We found that the miRNA signature is peculiar of each catabolic condition. We then focused on denervation and we reve

ORGANISM(S): Mus musculus

SUBMITTER: Gerolamo Lanfranchi 

PROVIDER: E-GEOD-51648 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress