Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection

ABSTRACT: The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of KaposiM-bM-^@M-^Ys sarcoma-associated herpesvirus (KSHV). While the KSHV genome is chromatin-free in the virions, the viral DNA in latently infected cells has a chromatin structure that is characterized by a specific pattern of activating and repressive histone modifications that ultimately promote latent gene expression while suppressing lytic gene expression. To investigate the molecular events involved in the establishment of the latent chromatin structure during the pre-latency phase of KSHV infection, we performed a comprehensive epigenetic study to analyze the recruitment of chromatin regulatory factors onto the KSHV genome at various time-points following de novo infection of

ORGANISM(S): Homo sapiens

SUBMITTER: Zsolt Toth 

PROVIDER: E-GEOD-51660 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress