Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene Profiling in Mouse Fetal Ductus Arteriosus

ABSTRACT: The ductus arteriosus (DA) is a fetal vascular shunt that is located between the main pulmonary artery and the aorta. Oxygenated fetal blood from the placenta is shunted past the uninflated fetal lungs, crosses the DA, and is then available to the peripheral organs. In utero closure of the DA is deleterious, but postnatal closure of the DA is necessary for establishment of pulmonary circulation and the transition to newborn life. We used microarrays to compare ductus arteriosis (DA) and aortic gene expression at a single time point (day 19 of gestation, which is the day of expected delivery). DA and corresponding aortic vascular segments from fetal mice on day 19 of gestation were collected from every pup in a litter (up to the first 10 pups). These samples were pooled and considered representative of the DA's or aortas from one pregnant female. Tissues were homogenized via 27g needle, per GentraSystems Versagene kit

ORGANISM(S): Mus musculus

SUBMITTER: John Reese 

PROVIDER: E-GEOD-51664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone.

Shelton Elaine L EL   Ector Gerren G   Galindo Cristi L CL   Hooper Christopher W CW   Brown Naoko N   Wilkerson Irene I   Pfaltzgraff Elise R ER   Paria Bibhash C BC   Cotton Robert B RB   Stoller Jason Z JZ   Reese Jeff J  

Physiological genomics 20140501 13

Failure of the ductus arteriosus (DA) to close at birth can lead to serious complications. Conversely, certain profound congenital cardiac malformations require the DA to be patent until corrective surgery can be performed. In each instance, clinicians have a very limited repertoire of therapeutic options at their disposal - indomethacin or ibuprofen to close a patent DA (PDA) and prostaglandin E1 to maintain patency of the DA. Neither treatment is specific to the DA and both may have deleteriou  ...[more]

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