Profiling the transcriptome: synaptoneurosomes capture the molecular effects of alcohol consumption

ABSTRACT: Action of alcohol on synaptic mRNA in the amygdala of mice Chronic alcohol consumption induces changes in gene expression, causing persistent long-term neuro-adaptations and the remodeling of synaptic structures. These alcohol-induced synaptic changes may rely specifically on the local translation of mRNAs in the synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes (SN) and paired total homogenates (TH) of amygdala to analyze the synaptic adaptations induced by chronic voluntary alcohol consumption in mice. In the SN both the number of alcohol-responsive mRNAs and the magnitude of fold-change were greater than in the TH. Accordingly, the SN detected many genes with coordinated patterns of expression producing a highly connected mRNA network in gene co-exp

ORGANISM(S): Mus musculus

SUBMITTER: Dana Moat 

PROVIDER: E-GEOD-51730 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress