ChIP-seq of MOF, MSL and NSL complex members in mouse ES cells and neuronal progenitors

ABSTRACT: We assessed the genome-wide binding of the histone acetylase MOF and members of its two associated complexes, the male-specific lethal and the non-specific lethal complex (MSL, NSL). We generated ChIP-seq profiles for MOF, MSL1, MSL2, KANSL3, and MCRS1 from mouse embryonic stem cells and neuronal progenitor cells. By using two replicates per sample and stringent filtering criteria, we identify five basic groups of genome regions where the proteins show either mutual or exclusive binding. We find that the NSL complex members (KANSL3, MCRS1) target the TSSs of broadly expressed genes with housekeeping functions in both cell types. MOF and particularly the MSL complex target a subset of these NSL-complex-targets, too. In addition, we find several thousand TSS-distal binding sites, particular

ORGANISM(S): Mus musculus

SUBMITTER: Friederike Dündar 

PROVIDER: E-GEOD-51746 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress