A computational genomics approach to identify cis-regulatory modules - a case study using E2F1

ABSTRACT: We first trained a set of experimentally identified E2F1 targets by a ChIPModules approach, the identified module of E2F1 and AP-2alpha was validated by ChIP-chip assays. We have performed 3 sets of ChIP-chip experiments in MCF-7 for E2F1 and AP-2alpha respectively. The common genes bound by both E2F1 and AP-2alpha were then identified as a co-localized set of genes. We also performed ChIP-PCR conformation for randomly selected 10 targets.

ORGANISM(S): Homo sapiens

SUBMITTER: Alina Rabinovich 

PROVIDER: E-GEOD-5175 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress