Molecular patterns in human ulcerative colitis and correlation with response to infliximab

ABSTRACT: Background & Aims. As a T cell-mediated disease of the colonic epithelium, ulcerative colitis (UC) is likely to share pathogenic elements with other T cell-mediated inflammatory diseases. Recently we showed T cell-mediated rejection of kidney and heart transplants share large scale molecular changes. We hypothesized that UC would manifest a similar disturbance, and that these features would correlate with response to infliximab. Results. UC biopsies manifested coordinate transcript changes resembling rejecting transplants, with T cell, IFNG-induced, macrophage, and injury transcripts increasing while parenchymal transcripts decreased. The disturbance expressed as principal component 1 correlated with conventional assessments e.g. Mayo scores, serum albumin, and lymphoplasmacytic infiltra

ORGANISM(S): Homo sapiens

SUBMITTER: Jessica Chang 

PROVIDER: E-GEOD-51785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress