Transcriptional dissection of pancreatic tumors engrafted in mice

ABSTRACT: Engraftment of primary pancreas ductal adenocarcinomas (PDAC) in mice to generate patient derived xenograft (PDX) models is a promising platform to for biological and therapeutic studies in this disease. However, these models are still incompletely characterized. Here, we measured the impact of the murine environment on the gene expression of the engrafted human tumoral cells. We have analyzed gene expression profiles from 35 new PDX models and compared them with previously published microarray data from PDAC and hepatocellular carcinoma (HCC). Our results showed that PDX models derived from PDAC, or HCC, were clearly different to the cell lines derived from the same cancer tissues. Indeed, PDAC- and HCC-derived cell lines are indistinguishable one from the other based in their gene expres

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Hidalgo 

PROVIDER: E-GEOD-51798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress